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Intake of CLA‐fortified butter decreases serum levels of leptin in healthy subjects
Author(s) -
Penedo Leticia,
Nunes Juliana C,
Gama Marco A S,
QuiricoSantos Thereza,
Torres Alexandre Guedes
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.lb216
Subject(s) - leptin , adiponectin , adipokine , conjugated linoleic acid , endocrinology , medicine , obesity , lean body mass , body weight , chemistry , linoleic acid , fatty acid , insulin resistance , biochemistry
Conjugated linoleic acid (CLA) might promote changes on body composition and on the components of the metabolic syndrome. We aimed to investigate the effect of supplementation of 1g/day of CLA, through the daily intake of a fortified butter, on the lean and fat body mass, and on serum levels of the adipokines adiponectin, leptin, and TNF‐α of healthy young adults. Sixteen men and women aged 23 to 36 years were studied, and the experimental design consisted of a baseline collection, a washout period of 8 weeks and the 8 week supplementation period. Supplementation with CLA did not alter body fat mass (P= 0.1884; one way ANOVA) assessed by dual‐energy X‐ray absorptiometry analysis (DXA). However, consumption of the CLA‐fortified butter reduced (P= 0,0004) serum levels (average ± SD) of leptin, from 8.16 ± 2.99 to 4.80 ± 1.93, but did not change significantly serum levels of adiponectin and TNF‐α. Our results indicate that naturally CLA‐enriched butter promoted benefits concerning the management of serum leptin levels, which might help the control of adiposity and to prevent obesity. Financial support: CNPq, FAPERJ, CAPES (Brazil)