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NAFLD and Celiac Disease in adult patients
Author(s) -
Trovato Guglielmo M.,
Trovato Francesca M,
Pirri Clara,
Martines G. Fabio,
Pennisi Alessia,
Puglisi Claudia,
Catalano Daniela
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.lb210
Subject(s) - insulin resistance , medicine , fatty liver , gastroenterology , metabolic syndrome , malnutrition , anthropometry , disease , insulin , endocrinology , obesity
Celiac Disease (CD) is a syndrome affecting any age, with a prevalence of 1/100–150. Non‐Alcoholic‐Fatty‐Liver‐Disease (NAFLD) is a condition related to metabolic syndrome, insulin resistance and nutritional behavior as steatogenic factors. Fatty liver in CD was ascribed to malnutrition. The aim is to investigate relationship of nutritional state and insulin resistance in newly diagnosed adult's CD and NAFLD. Methods 1941 adult patients referred both for comprehensive Ultrasound procedure assessment and nutritional counseling were studied; NAFLD and CD diagnosis were made according to established criteria, including biopsy. Malnutrition was assessed by Bio‐impedance and anthropometry, bio‐markers (Albumin, B12 Vit., Folic Acid) and insulin resistance, using the Homeostasis Model Assessment (HOMA; cut off value for HOMA at 1.7). Results the prevalence of CD is 21/1941, 1.17%, (i.e. 1/85). The prevalence of NAFLD is 219/1941, 11.28%, (i.e. 1/9); NAFLD prevalence is 3/21 (14.3%) CD patients (p: n.s.). No sign of malnutrition is observed in CD‐NAFLD patients. Greater BMI (29,67±4,72 vs. 23,84±4,61; p<0.0001) and slightly greater insulin resistance, assessed by HOMA (2.31±1.04 vs. 1.84±1.01; p: 0.051) are overall present in NAFLD vs. CD. Conclusion NAFLD and insulin resistance are observed in CD without clear signs of malnutrition. This suggests the possible involvement of other steatogenic factors.