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Bronchial wall remodeling is reduced by dexamethasone treatment during larvae pulmonary migration of Strongyloides venezuelensis
Author(s) -
TeféSilva Cristiane,
Beneli Cristina T.,
Celes Mara R.,
Machado Eleuza R.,
Ueta Marlene T.,
Floriano Elaine M.,
Sorgi Carlos A.,
Faccioli Lúcia H.,
Ramos Simone G.
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.999.5
Subject(s) - dexamethasone , lung , medicine , hyperplasia , immunology , inflammation , pathology
Strongyloidiasis is an intestinal parasitosis with an obligatory pulmonary cycle. The immune response is associated with Th2‐type. Although the inflammatory response seems similar to asthma, the possible mechanism of bronchial remodeling during pulmonary migration of larvae has not been established. The aim of this study was to delineate the mechanisms involved in airway remodeling during the passage of Strongyloides venezuelensis larvae and to determine the ability of dexamethasone (dexa) to interfere with this process. Rats were divided into four groups: control, control+dexa, infected, infected+dexa. The groups were inoculated with 9,000 S. venezuelensis larvae and treated with 2mg of dexa. At 1, 3, 5, 7, 14 and 21 days, the rats were killed. Morphometric analyses and immunohistochemistry were conducted, and cytokines were evaluated by ELISA. Goblet cell and smooth muscle hyperplasia, collagen deposition were seen in thickenings of the bronchial wall, and IL‐1β, IL‐4 and VEGF levels were elevated throughout the course of infection. Both the morphologic alterations and the immunomodulatory response to the infection were drastically reduced in the dexamethasone‐treated animals. The airway remodeling occurs during passage of S. venezuelensis as a consequence of Th‐2 type inflammation. Dexamethasone treatment can inhibit this process, acting primarily by suppressing cytokines.