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Development of a risk assessment framework for folate metabolism
Author(s) -
Hu Jing,
Sahyoun Nadine R
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.997.3
Subject(s) - food fortification , medicine , environmental health , risk assessment , neural tube , folic acid , vitamin b12 , malnutrition , population , endocrinology , biology , computer science , embryo , computer security , microbiology and biotechnology
Fortification of food with folic acid has lead to a decrease in neural tube defect (NTD) by 30%. There is a call to increase fortification of food to further decrease the risk of NTD. However, there is a concern that increasing folic acid intake will lead to cognitive impairment caused by vitamin B12 deficiency among older adults and potentially increase the risk of colorectal cancers. Therefore, it is crucial to explore ways to find the minimum effective dose of folate intake to prevent NTD without posing excessive among vulnerable population. Nutrient risk assessment model may be a way to develop risk and benefit curves of folate to find a healthy range of intake. This study is the first step in developing a risk assessment framework following the Key Events Dose‐Response Framework (KEDRF) developed by the International Life Science Institute's Global Threshold Project. The key events and control points in the metabolic pathway have been identified. The data will contribute to the construction of risk and benefit curves for detection of optimal folate intake.