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Effects of maternal consumption of low‐protein diet with soy as protein source on hepatic glucose and lipid metabolism of the rat offspring
Author(s) -
Kwon Young Hye,
Yoon Mi,
Won Saebom
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.990.14
Subject(s) - offspring , endocrinology , medicine , soy protein , lipid metabolism , lactation , dyslipidemia , glucose homeostasis , biology , carbohydrate metabolism , insulin , triglyceride , insulin resistance , pregnancy , cholesterol , diabetes mellitus , biochemistry , genetics
Maternal protein restriction (PR) induces dyslipidemia and impaired glucose homeostasis in offspring, which is associated with metabolic disease development in later life. Recent studies showed that maternal soy protein diet improves insulin sensitivity and lipid profile of offspring. Therefore, we investigated effects of maternal PR diet with soy as protein source on hepatic glucose and lipid metabolism in offspring. SD rats were fed 20% casein, 20% isoflavone‐poor soy protein isolate (SPI) or 10% SPI during pregnancy and lactation. Male offspring was studied at postnatal d21. Body weight and relative liver weight were significantly lower in offspring of dam fed 10% SPI diet (10% SPI). Serum glucose, triglyceride (TG), insulin concentrations and HOMA‐IR were significantly lower in 20% SPI compared to those in 20% casein. SPI level did not significantly change serum glucose concentration and HOMA‐IR. Serum and hepatic TG concentrations were significantly lower in 10% SPI compared to those in 20% SPI. Hepatic mRNA expression of peroxisome proliferator‐activated receptor alpha, a transcription factor involved in the regulation of glucose and lipid homeostasis, was not significantly different among groups. Therefore, these findings indicate that maternal consumption of soy protein may alleviate the PR‐mediated metabolic disease development in rat offspring. Supported by Korea Research Foundation.