Premium
Nutritional predictors of muscle protein metabolism and function in older adults
Author(s) -
Markofski Melissa M,
Timmerman Kyle L,
Fry Christopher S,
Dickinson Jared M,
Walker Dillon K,
Rasmussen Blake B,
Volpi Elena
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.983.18
Subject(s) - overweight , medicine , sarcopenia , lean body mass , dual energy , gerontology , obesity , endocrinology , physical therapy , zoology , body weight , biology , bone mineral , osteoporosis
Sarcopenia contributes to frailty in older adults and is associated with alterations in muscle protein metabolism. The purpose of this research was to examine the potential predictors of muscle protein synthesis and function in elders. Methods We report preliminary data from a subset of 8 healthy, sedentary subjects (69.5±3.4 yrs, BMI ≤30kg·m −2 ) enrolled in a larger study who met their dietary requirements. Linear regressions were carried out on the following variables: muscle protein fractional synthetic rate (FSR), muscle function tests, VO 2 peak, daily step count, dual energy x‐ray absorbometry (DEXA), 3‐day food diary, and blood biochemical analyses. Results The best linear regressors of FSR were soluble fiber (R 2 =−0.59, P =0.03) and vitamin D intake (R 2 =0.60, P =0.01). The best multiple regressors were soluble fiber and leucine intake (R 2 =0.85, P =0.009). When the subjects were divided by BMI into overweight (n=4) or normal weight (n=4), the overweight subjects had a lower relative lean body weight (62.2±6.2% vs. 70.4±8.3) and slower 20‐meter load carry with weight time (11.4±2.2 sec vs. 10.9±1.1). Summary In a group of healthy older adults who are meeting their recommended nutritional requirements, dietary factors influence FSR. Further, overweight subjects have additional negative health and functional outcomes. This study was supported by NIH R01 AG030070 and P30 AG024832.