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Minimal Enteral Glutamate Slows Gastric Emptying in Preterm Pigs
Author(s) -
Burrin Douglas,
BauchartThevret Caroline,
Stoll Barbara,
Benight Nancy
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.983.17
Subject(s) - gastric emptying , medicine , glutamine , enteral administration , glutamate receptor , endocrinology , monosodium glutamate , basal (medicine) , parenteral nutrition , chemistry , stomach , biochemistry , receptor , amino acid , insulin
Glutamate (GLU) is the major excitatory neurotransmitter in the body. GLU receptors and transporters are present in the gut. Emerging evidence suggests that GLU may play a functional role in promoting gastric emptying and digestion. We hypothesized that dietary GLU stimulates gastric emptying in the developing gut. 10‐d preterm, parenterally‐fed pigs received partial enteral nutrition (25%) as milk‐based formula supplemented with monosodium glutamate (MSG) at 0, 2, 4 and 6 times the basal GLU intake (n=5–8 pigs/group) for 7 d. Calorimetry and 13 C‐octanoic acid breath test were performed on d 3, 5, 7 and 9 of life. We found no differences in body weight gain, organ weight and arterial plasma GLU and glutamine concentrations between the treatment groups. However, portal GLU concentration was significantly higher in pigs fed the MSG 4 and 6 doses. There was no treatment effect on VO 2 uptake, VCO 2 production, respiratory exchange ratio and heat production. The average lag time (T lag ) and gastric half emptying time (T 1/2 ) between all treatment groups were 121 and 188 min, respectively. T lag and T 1/2 tended to increase with MSG supplementation in a dose dependent manner. At d 9, the cumulative % recovery of 13 C‐octanoic acid was lower in MSG‐4 and MSG‐6 groups. Our results suggest that enteral MSG supplementation slows gastric emptying in the developing gut. (Funded by Ajinomoto)