Premium
Dietary cysteine is utilized more efficiently by children with edematous severe childhood undernutrition compared to those with non‐edematous severe childhood undernutrition during nutritional rehabilitation
Author(s) -
Hsu Jean W,
Badaloo Asha,
TaylorBryan Carolyn,
Reid Marvin,
Forrester Terrence,
Jahoor Farook
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.983.1
Subject(s) - splanchnic , edema , malnutrition , medicine , brain edema , severe acute malnutrition , gastroenterology , cysteine , endocrinology , glutathione , chemistry , biochemistry , hemodynamics , enzyme
Compared to children with non‐edematous severe childhood undernutrition (SCU), those with edematous SCU have slower glutathione synthesis and lower intracellular cysteine (Cys) indicating a shortage in Cys supply. We tested the hypothesis that children with edematous SCU will utilize dietary Cys more efficiently to maximize supply during early nutritional rehabilitation. Cys flux, oxidation and its splanchnic extraction were measured in 5 children with non‐edematous and 7 with edematous SCU during early metabolic stabilization (3.8±0.5 d post‐admission) and during mid catch‐up growth (20.1±2.0 d post‐admission) using primed‐continuous 6 h tracer infusions of 2 H 2 ‐Cys intragastrically and U‐ 13 C 3 ‐Cys intravenously. Starting 2 h before the isotope infusions, 33% of daily food intake was given by constant intragastric infusion for 8 h.Cysteine (μmol/kg/h)Splanchnic Uptake Exogenous Intake Oxidation BalanceEarly Stabilization No Edema 4.1±0.5 13.5±0.4 5.6±1.1 7.9±1.5 Edema 5.9±0.9 14.5±0.5 1.6±0.3 12.9±0.8 P <0.01 0.01Mid Catch‐up Growth No Edema 9.6±1.0 25.5±0.8 8.9±0.8 16.6±1.2 Edema 9.8±1.4 26.3±0.4 2.8±0.6 23.5±0.8 P <0.01 0.01Mean±SEMWe conclude that children with edematous SCU utilize dietary cysteine more efficiently than children with non‐edematous SCU during nutritional rehabilitation. Supported by NIH Grant # R01 DK056689