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Hyperlycemia affects CVD risk by modulating cholesterol LDL and HDL lipoprotein distribution in Mexican‐American adults
Author(s) -
Neupane Srijana,
Shaibi Gabriel Q,
VegaLópez Sonia
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.982.8
Subject(s) - quartile , medicine , cholesterol , overweight , endocrinology , insulin resistance , lipoprotein , chemistry , insulin , obesity , confidence interval
To assess if CVD risk is associated with glucose and lipoprotein particle size in Mexican Americans, we randomly selected 80 overweight adults (age = 41.6±7.8 y; BMI = 32.2±7.1 kg/m 2 ; LDL‐C = 112±31 mg/dL; HDL‐C = 35±11 mg/dL; fasting glucose [FG] = 101±38 mg/dL; 2‐hr glucose [2hGlu] = 154±70 mg/dL) from the Arizona Insulin Resistance Registry. HDL‐C was negatively correlated with FG (r = −0.38; p = 0.001) and 2hGlu (r = −0.30; p = 0.01). LDL‐C was positively correlated with FG (r = 0.26; p = 0.02) and 2hGlu (r = 0.40; p < 0001). When stratified by FG, participants in the lowest quartile had a significantly lower percentage of cholesterol in smaller LDL particles (1.2±1.8 %) than those in the 3 rd and 4 th quartiles (6.1±4.3 % and 5.4±4.5 %, respectively; p = 0.004), with no differences in the amount of cholesterol in larger LDL particles. Participants in the lowest quartile of FG had the highest amount of HDL‐C in larger HDL particles (26.1±8.3 %) relative to the 3 rd and 4 th quartiles (17.7±6.6 % and 16.4±6.0 % respectively; p < 0.001) and the least amount in smaller HDL particles (73.8±8.4 %) compared to the 3 rd and 4 th quartiles (82.3±6.4 % and 83.6±5.9 %, respectively; p = 0.002). Findings were similar when stratifying by 2hGlu. Thus, hyperglycemia may affect CVD risk by modulating cholesterol distribution in LDL and HDL particles in this population. Funded by ASU and the Health Research Alliance AZ/Arizona Insulin Resistance Registry.