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Effects of alternate day modified fasting on LDL particle size and distribution in obese adults
Author(s) -
Varady Krista A,
Bhutani Surabhi,
Klempel Monica C
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.982.7
Subject(s) - medicine , waist , endocrinology , coronary heart disease , obesity , ldl cholesterol , intermittent fasting , cholesterol , zoology , biology
Alternate day modified fasting (ADMF) beneficially modulates several indicators of coronary heart disease (CHD) risk, but its effects on LDL particle size have never been tested. Accordingly, we examined the effects of ADMF on LDL particle size and distribution in obese adults. Sixteen obese subjects participated in a 10‐week trial with three consecutive phases: 1) 2‐week control phase, 2) 4‐week ADMF controlled feeding phase, and 3) 4‐week ADMF self‐selected feeding phase. After 8 weeks of diet, body weight and waist circumference were reduced (P < 0.05) by 5.6 ± 0.9 kg, and 4.0 ± 0.9 cm, respectively. LDL cholesterol and triacylglycerol concentrations decreased (P < 0.05) by 25 ± 10%, and 32 ± 6%, respectively. Peak LDL particle size increased (P < 0.05) from 266 ± 1 to 268 ± 1 Å. Additionally, the proportion of small LDL particles decreased (P < 0.05) from 13 ± 2% to 9 ± 3%, while the proportion of large LDL particles increased (P < 0.05) from 68 ± 4% to 76 ± 4% post‐treatment. These findings suggest that ADMF is an effective diet strategy for increasing LDL particle size and decreasing the proportion of small, dense LDL particles in obese adults.