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The relationship of obesity, diabetes status and ethnicity with high sensitivity C‐reactive protein
Author(s) -
Vaccaro Joan A,
Huffman Fatma G
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.982.10
Subject(s) - medicine , body mass index , diabetes mellitus , obesity , national health and nutrition examination survey , c reactive protein , ethnic group , demography , population , gerontology , endocrinology , inflammation , environmental health , sociology , anthropology
Objectives C‐reactive protein (CRP) increases during systemic inflammation. There is growing evidence that high levels of CRP in the blood are indicative of and risk factors for CVD. The primary aim of this study was to examine the relationship of obesity, ethnicity, gender, diabetes status and CRP. Methods Secondary analysis of data acquired from the National Health and Nutrition Survey (NHANES) 2007–8, a stratified, multistage probability sample of the civilian non‐institutionalized U.S. population. Complex sample Analysis of variance (ANOVA) models were performed to determine differences of high‐sensitivity CRP (hs‐CRP) for three ethnic categories: Black non‐Hispanic (BNH), Mexican American (MA), White, non‐Hispanic (WNH). Results For the combined sample, body mass index and diabetes predicted hsCRP. Together with age, the model explained 31.0% of the variance of hsCRP (R 2 ) p<0.001. When race was added, diabetes was no longer an independent predictor. Diabetes interacted with race and gender to predict hsCRP (p=0.042). Conclusions Levels of hsCRP differed by diabetes status, ethnicity/race, BMI and gender. The findings suggest that obesity, as measured by BMI, is a modifiable risk factor for hsCRP.