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Suppressive effects on the biosynthesis of inflammatory mediators by Korean traditional plant‐A extract in macrophage cells
Author(s) -
Kim GunHee,
Hwang Keum Hee,
Lee JeHyuk
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.981.3
Subject(s) - nitric oxide , macrophage , chemistry , biosynthesis , nitric oxide synthase , anti inflammatory , antioxidant , nitrite , cyclooxygenase , biochemistry , pharmacology , traditional medicine , biology , enzyme , medicine , in vitro , organic chemistry , nitrate
The aim of this study is to elucidate the anti‐inflammatory effects of Korean traditional plant A extract. Plant‐A extract had the potent antioxidant activity. Plant‐A extract inhibited potently LPS‐induced nitrite production from RAW 264.7 macrophage cells. The inhibition of nitric oxide (NO) production by Plant‐A extract was supposed to be due to chemical scavenge of NO and the suppression of inducible NOS (iNOS) transcription level in LPS‐induced macrophage cells. In addition, we investigated the inhibition for biosynthesis of Prostaglandin E 2 (PGE 2 ) and cyclooxygenase‐2 by Plant‐A extract. We have the plan to study the suppression of inflammatory mediators by Plant‐A extract. Plant‐A is expected to be useful as a functional food material and an alternative medicine for the relief and retardation of immunological inflammatory responses.