Premium
Effect of Ginkgo Biloba leaf powder and extract on plasma and liver lipids, platelet aggregation and erythrocyte Na+ efflux in rats fed hypercholesterolemic diet
Author(s) -
Kim Ji Mi,
Ryou Sung Hee,
Kang Young Hee,
Kang Jung Sook
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.980.8
Subject(s) - ginkgo biloba , chemistry , platelet , medicine , cholesterol , endocrinology , efflux , intracellular , pharmacology , biochemistry , biology
This study was conducted to investigate the effects of Ginkgo biloba (Gb) leave powder (10%) and extract (3%) on plasma and liver lipids, platelet aggregation, erythrocyte Na efflux and angiotensin converting enzyme (ACE) in SD rats fed 0.5% cholesterol diet. Average daily gain was significantly lower in rats fed Gb extract than the control (p<0.05) with no difference in food intake. Plasma HDL cholesterol was increased in rats fed Gb powder (p<0.05) compared with control. Platelet aggregation in maximum and initial slope were significantly decreased compared with the control (both, p<0.05). Intracellular Na was significantly higher in rats of Gb extract than the control (p<0.05) without difference in intracellular K. Erythrocyte Na‐K ATPase and total Na efflux were significantly increased in rats of Gb extract compared with other groups (p<0.01, p<0.05). Plasma glucose was significantly lower in Gb powder than the control. Plasma GOT, GPT and glucose were significantly lower in Gb extract compared with the control (all p<0.05). Ginkgo biloba which contains bioactive ginkgolide and bilobalide seems to have protective effects from cardiovascular diseases with favorable actions on HDL cholesterol, platelet aggregation and erythrocyte Na channels.