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Effect of chestnut pericarp on plasma and liver lipids, platelet aggregation and erythrocyte Na leak in rats fed cholesterol containing diet
Author(s) -
Hwang Hye Jin,
Kang Min Sook,
Kang Young Hee,
Kang Jung Sook
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.980.7
Subject(s) - tbars , chemistry , cholesterol , antioxidant , hemolysis , platelet , lipid peroxidation , tannin , erythrocyte membrane , food science , medicine , biochemistry , membrane
We compared bioactivity of 10% chestnut pericarp (CP) powder and 3% CP extract in hypolipidemic, antiplatelet and antioxidant effects by examining lipid profile, platelet aggregation, erythrocyte Na leak and TBARS production in rats fed 0.5% cholesterol diet. Plasma total cholesterol was significantly decreased (p<0.05) with significantly increased in HDL/total cholesterol ratio (p<0.05) in rats fed CP powder compared to the control. Maximum platelet aggregation tended to decrease in rats of CP powder and extract, but no significant difference. There were no difference in hemolysis and erythrocyte Na leak among groups, suggesting no antioxidant effect on membrane. Liver TBARS production was significantly reduced in rats fed CP powder and CP extract compared with the control (p<0.05). GOT and GPT were significantly decreased in rats fed GP power compared with other groups (p<0.05, p<0.01). In conclusion, chestnut pericarp that is rich in tannin may have cholesterol lowering and liver protective effects. Chestnut pericarp which has been inedible waste material can be used as a complementary and alternative medicine for cardiovascular diseases.