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Ethanol extracts of yam potently reduce atherosclerosis in ApoE‐deficient mice
Author(s) -
Park HyeJin,
Byeon HyeEun,
Koo HyunJung,
Kwon Soon Tae,
Pyo Suhkneung
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.980.1
Subject(s) - proinflammatory cytokine , inflammation , cholesterol , apolipoprotein e , dioscorea , monocyte , apolipoprotein b , chemistry , endocrinology , medicine , pharmacology , disease , pathology , alternative medicine
Atherosclerosis is a chronic inflammatory disease initiated by vascular inflammation and monocyte recruitment. Yams belong to the plant family Dioscoreae and have been known to have a variety of nutritional benefits with high levels of vitamins, dietary fibers, and minerals. However, the effect of yam extracts on inflammatory diseases is not known yet. Herein we evaluate whether extracts from edible part (H1) or bark region (H2) of yam ( Dioscorea batatas Decne ) have a protective effect against atherosclerosis in experimental mice. 51 male ApoE −/− mice and 17 control (C57BL/6J) mice were fed a high‐fat/high‐cholesterol diet for 21 weeks. To examine the effect of dietary yam extracts on atherosclerosis, 17 of the ApoE −/− mice were given H1 and another 17 of the ApoE −/− mice were given H2 (oral administration of 200 mg/kg body weight, 3 times per week). Both H1 and H2 showed suppressive effects on the lipid deposition and the local infiltration of monocytes/macrophages in aorta. In addition, administration of H1 and H2 decreased serum levels of CRP, MCP‐1 and total cholesterol, while it slightly increased the level of HDL. Moreover, they attenuated the level of oxLDL in serum. The present study demonstrates that yam extracts, H1 and H2, might have a protective effect against atherosclerosis by regulating proinflammatory mediators in serum as well as preventing atherosclerotic lesion development.