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Higher plasma homocysteine is associated with increased risk of colorectal polyps
Author(s) -
Huang YiChia,
Lin ChunChe,
Chen FangPei,
Chen TanHsia
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.978.8
Subject(s) - colorectal adenoma , medicine , homocysteine , gastroenterology , colorectal cancer , adenomatous polyps , b vitamins , body mass index , risk factor , vitamin , colonoscopy , endocrinology , cancer
Colorectal adenomas are considered as precursors of colorectal cancer. B‐vitamins (i.e., folate, vitamin B‐6 and B‐12) involve in the homocysteine metabolism and play as coenzymes in one‐carbon metabolism, which may have a critical role in the colorectal polyps progression. The purpose of this study was to examine the effects of B‐vitamins and homocysteine on the risk of colorectal polyps. This study was an observational case‐control design. Forty‐seven subjects with colorectal polyps [29 adenomatous polyps (AP), 18 hyperplastic polyps (HP)] and 95 age‐, sex‐matched healthy subjects were recruited. Subjects with AP and HP had significantly higher plasma homocysteine levels than did healthy subjects. There was no significant difference in serum folate and vitamin B‐12 and plasma pyridoxal 5′‐phosphate among the three groups. B‐vitamins had no significant effect on the risk of colorectal polyps. However, subjects with higher plasma homocysteine (OR, 2.18; 95% CI, 1.23 – 3.88) level exhibited significantly increased risk of colorectal polyps after body mass index, diastolic blood pressure, total cholesterol and B‐vitamins were additionally adjusted. Plasma homocysteine, but not B‐vitamins, is a strong predictor of the risk of colorectal polyps while subjects had adequate B‐vitamins status. This study was supported by National Science Council (NSC 97‐2320‐B‐040‐031‐MY3), Taiwan.