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Association of hemochromatosis (HFE) gene polymorphisms with oral cancer risk
Author(s) -
Ashmore Joseph,
Jones Nathan,
Lazarus Philip,
Muscat Joshua
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.978.7
Subject(s) - medicine , cancer , gastroenterology , genotyping , genotype , hereditary hemochromatosis , case control study , loss of heterozygosity , hemochromatosis , compound heterozygosity , genetics , gene , allele , biology
Mutations in the HFE gene are associated with iron overload, which has been previously linked to various forms of cancer including oral cancer. African Americans (AA) have been shown to have increased prevalence of oral cancer compared to Caucasians (C). The objectives of this study were to determine the prevalence of HFE polymorphisms in African Americans, and determine whether associated with oral cancer in Caucasians and African Americans. ABI Taqman genotyping assays were used to genotype the two most studied HFE polymorphisms, C282Y and H63D in a population from the Northeastern United States. The present study included 301 subjects with oral cancer (“cases”) and 437 controls comprised of 501 men and 237 women. In this study, 234 participants were African American (AA cases = 100) and 504 were Caucasian (cases = 201). H63D status did not differ between cases and controls (C ‐ 17.2% vs. 20.4%, p = 0.403; AA ‐ 8.5% vs. 5.7%, p = 0.417) nor did C282Y status (C ‐ 6.0% vs. 5.4%, p = 0.778; AA ‐ 2.0% vs. 3.7%, p = 0.702). Compound heterozygosity for germ line mutations of the HFE gene was not significantly different between cases and controls (C ‐ 23.6% vs. 25.5%, p = 0.650; AA ‐ 10.6% vs. 9.8%, p = 0.831). Our case‐control study suggests that HFE C282Y and H63D polymorphisms are not associated with oral cancer status in either Caucasians or African Americans.