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Dietary Intake and Serum Levels Status of Folate and Vitamin B12 among Jordanian Colorectal Cancer Patients: a case‐control study
Author(s) -
Waly Mostafa I,
Arafa Mostafa A,
Jriesat Sahar B,
AlKhafajei Ahmed M,
Sallam Sunny A
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.978.5
Subject(s) - vitamin b12 , colorectal cancer , medicine , gastroenterology , cancer , vitamin , case control study , concomitant , vitamin d and neurology , risk factor , etiology , physiology , endocrinology
Low daily dietary intakes of folate and vitamin B12 have been associated with an increased risk of colorectal cancer in animal and human studies. The retrospective dietary intake of folate and vitamin B12 was investigated as well as the biochemical measurements of these nutrients in colorectal cancer patients and controls group in Jordan. Four hundred and forty subjects were recruited for this case‐control study, 220 colorectal cancer patients and 220 controls. The mean daily intake of folate and vitamin B12 was significantly lower amongst patients (189.2 ± 11.7 μg/day and 1.09 ± 1.1 μg/day respectively) when compared to the controls group (212.5 ± 13.1 μg/day and 1.49 ± 1.3 μg/day respectively). The same pattern was observed for folate serum measurements of colorectal cancer patients (6.6 ± 0.3 μg/L) as compared to controls (16.2 ± 2.8 μg/L) and for serum vitamin B12 of cases (233.7±17.9 pg/mL) as compared to controls group (458.9±30.9 pg/mL). This study suggests that the studied colorectal cancer patients had a low dietary intake of folate and vitamin B12 that is concomitant with low serum levels of these two nutrients, a well established etiological factor for different types of human cancer, including colorectal cancer.