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Obesity Decreases Serum Selenium levels in DMBA‐Induced mammary Tumor using Obese Zucker Rat Model
Author(s) -
Hakkak Reza,
Zeng Huawei,
Lacher Craig,
Johnson LuAnn,
Korourian Soheila
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.977.12
Subject(s) - dmba , medicine , endocrinology , ovariectomized rat , selenium , mammary tumor , obesity , chemistry , carcinogenesis , estrogen , cancer , breast cancer , organic chemistry
Recently, we reported that obese Zucker rats had increased susceptibility to DMBA‐induced mammary tumors compared to lean Zucker rats. Several data suggest that lower serum selenium may play an important role in increasing the risk of several types of cancers (e.g, colon, breast and prostate cancers). In the present study, we used this model to investigate whether serum selenium has been affected by obesity. Lean and obese rats were sham operated or ovariectomized at age 40 days and were gavaged at age 50 days with 65 mg/kg DMBA. Rats were weighed and palpated twice weekly for detection of mammary tumors and killed 135 later. The serum selenium was measured by graphite furnace atomic absorption spectrometry. At the end of the experiment, 36% of the obese ovariectomized (O/O) rats developed mammary tumors while lean ovariectomized (L/O) rats developed no mammary tumors ( P <0.001). The Obese sham‐operated (O/S) rats developed mammary tumors (59%) compared to 30% of the lean sham‐operated (L/S) rats ( P <0.05). The serum selenium was not effected significantly by ovariectomy but obesity decreased the serum selenium levels when combined L/S and L/O (511 ± 71) vs. O/S and O/O (480 ± 145) (P<0.05). In summary, obesity decreases serum selenium levels using DMBA‐induced mammary tumors Zucker rat model. These data suggests that serum selenium may play an important role mammary carcinogenesis. (Supported by ABI to RH).