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Serum antioxidant status and its association with metabolic syndrome among US adults: Findings from recent national data
Author(s) -
Beydoun May A,
Shroff Monal R,
Chen Xiaoli,
Beydoun Hind A,
Wang Youfa,
Zonderman Alan B
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.975.3
Subject(s) - hyperuricemia , national health and nutrition examination survey , medicine , metabolic syndrome , endocrinology , national cholesterol education program , retinol , insulin resistance , carotenoid , zeaxanthin , physiology , vitamin , diabetes mellitus , uric acid , lutein , chemistry , environmental health , population , biochemistry
We examined the association between serum antioxidant status and the metabolic syndrome (MetS) using data from the National Health and Nutrition Examination Surveys (NHANES 2001–06) among adults aged 20–85 years. Sample sizes ranged between 3,008 and 9,099, depending on the outcome measure. MetS was defined with the National Cholesterol Education Program, Adult Treatment Panel III (NCEP ATP III) criteria. Elevated homeostatic model assessment insulin resistance (HOMA‐IR), C‐reactive protein (CRP) and hyperuricemia were also considered. Serum antioxidants included retinol, retinyl esters, carotenoids (α‐carotene, β‐carotene (cis+trans), β‐cryptoxanthin, lutein+zeaxanthin, total lycopene) and vitamin E and vitamin C. Multiple linear, zero‐inflated poisson and logistic regression models were conducted. MetS + adults had consistently lower serum carotenoid concentrations compared to MetS − adults. Vitamin E was not significantly associated with MetS, while retinol+retinyl esters were inversely related to MetS in men only. Retinol+retinyl esters were also inversely related to elevated CRP and positively associated with hyperuricemia. Vitamin C was inversely related to MetS, HOMA‐IR and hyperuricemia. Serum antioxidant levels, carotenoids in particular, need be monitored to assess the effectiveness of MetS primary and secondary prevention related to lifestyle changes.