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Relationship between serum and synovial fluid concentration of leptin and degree of osteoarthritis
Author(s) -
Schmidt Jenna,
Hooshmand Shirin,
Arjmandi Bahram
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.971.22
Subject(s) - synovial fluid , leptin , osteoarthritis , medicine , obesity , endocrinology , etiology , orthopedic surgery , gastroenterology , pathology , surgery , alternative medicine
Currently 27 million Americans are affected by osteoarthritis (OA) however, its etiology remains unclear and effective therapies to prevent or halt OA are not available. Evidence suggests that loss of body fat is more important to decrease risk of OA than general weight loss emphasizing the role of fat tissue and its secretions and suggesting a metabolic link between obesity and OA. The objective of this project was to explore the relationship between serum and synovial fluid concentrations of leptin and the degree of OA. Blood and synovial fluid samples were obtained by an orthopedic surgeon from a total of 40 men and women with knee OA undergoing arthroscopic or total knee replacement surgery. Synovial fluid and serum samples were analyzed in duplicate using ELISA method to determine the concentration of leptin. Our findings show a distinct correlation between BMI and serum leptin levels in both males and females (R=0.505, p=0.02 ; R=0.569, p=0.008 ). We found that in both men and women, the degree of OA was associated with serum leptin concentrations (R=0.487, p=0.02 ; R=0.498, p=0.04 ). Our data also show that females have higher levels of leptin in both serum and synovial fluid than males. Although our results are promising in terms of relation among leptin levels in synovial fluid and serum and the degree of OA, further studies are needed to investigate the exact role of leptin in increasing the severity of OA.