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The effect of an emulsified fish oil preparation on cardiovascular risk factors in an overweight young adult population
Author(s) -
Root Martin,
McGinn Megan,
Collier Scott,
Zwetsloot Kevin
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.971.19
Subject(s) - medicine , overweight , dosing , fish oil , blood pressure , pulse wave velocity , hemodynamics , population , body mass index , placebo , metabolic syndrome , cohort , endocrinology , blood lipids , physiology , obesity , cholesterol , biology , fish <actinopterygii> , alternative medicine , environmental health , pathology , fishery
Background Long chain omega‐3 fatty acids (O3) are known to have beneficial effects on a number of hemodynamic and vascular risk factors in at‐risk populations. The effects of a highly bioavailable emulsified preparation on a young adult population were less well known. Methods Young adults, age 18–30, with body mass indices (BMIs) greater than 23 (average = 28.1) were administered 1.7 g of fish oil O3 per day in an emulsified preparation (N=30) (Coromega, Inc.) or safflower placebo (N=27) for 4 weeks in a double‐blind randomized design. Blood was drawn and anthropometric measurements taken before and after the dosing period. Central pressures, arterial distensibility, inflammatory cytokines, fasting serum lipids, glucose, and C‐reactive protein were measured. Result None of the 5 American Heart Association metabolic syndrome measures improved over the dosing period. None of the hemodynamic measures (pulse wave velocity, augmentation index, or aortic systolic blood pressure), inflammatory cytokines (IL‐6, IL‐8, IL‐10, or TNF‐α), C‐reactive protein, or lipids (LDL, HDL, or triglycerides) improved over the dosing period. Conclusions These data suggest that O3 supplementation has no effect in this relatively healthy overweight cohort. This may be due to the relatively short supplementation time.