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Low vs. high glycemic load diets reduce insulin‐like growth factors and inflammatory factors in overweight persons in a controlled feeding study
Author(s) -
Neuhouser Marian L Stone,
Pollak Michael N,
Coronado Gloria,
Schwarz Yvonne,
Lampe Johanna W
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.94.7
Subject(s) - overweight , adiponectin , igfbp3 , medicine , glycemic load , glycemic , endocrinology , leptin , insulin , obesity , biomarker , insulin resistance , glycemic index , biology , growth factor , biochemistry , receptor
Our objective was to investigate whether associations of obesity with chronic disease risk biomarkers are mediated by dietary patterns that cause unfavorable metabolic profiles. Our randomized, cross‐over, controlled feeding study tested the effect of low‐ and high‐glycemic load (GL) experimental diets on disease risk biomarkers [glucose, insulin, IGF1, IGFBP3, leptin, adiponectin, interleukin‐6 and C‐reactive protein (CRP)]. Normal weight (n=40) and overweight/obese (n=42) men and women completed two 28‐day feeding periods – low GL and high GL. All meals were prepared in a metabolic kitchen and were isocaloric; both arms had identical macronutrients but differed in GL. Fasting blood was drawn before and after each feeding period. Linear mixed models tested the intervention effect on the biomarkers; models were adjusted for baseline biomarker concentrations, diet sequence, feeding period, age, sex and body fat mass. Compared to the high‐GL diet, the low‐GL diet significantly reduced IGF1 (p=0.04) and the IGF1:IGFBP3 ratio (p=0.01). Results were more pronounced among overweight/obese participants. When stratified by body fat mass, CRP was significantly lower for the low‐ vs. the high GL diet for those with high body fat (p=0.01). A dietary change emphasizing low GL foods may improve the metabolic and inflammatory profile of overweight and obese persons. Supported by NIH U54 CA116847, NIH R03 CA132158.