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The Functional Amino Acid Navigator
Author(s) -
Cargill Jason K,
Solimeo Renee,
Gomez Sal,
Palenchar Peter
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.924.1
Subject(s) - annotation , function (biology) , allosteric regulation , genome , protein function , computational biology , amino acid , enzyme , computer science , biology , bioinformatics , genetics , biochemistry , gene
The purpose of Functional Amino Acid Navigator (FAN) is to create a database that captures information about how enzymes function with respect to how they interact with small molecules, and then use that database to address questions related to how enzymes function, genome annotation and evolutionary changes in allosteric sites. FAN can give a detailed picture of enzymes interacting with small molecules at the atomic level where possible. The data in FAN is gathered from primary published literature detailing specific enzymes function. Information can also be added to FAN by outside individuals after registration. FAN will also analyze BLAST protein sequence alignments to help ensure correct protein annotation by identifying amino acids for which FAN contains a function and determining if they are conserved based on the BLAST alignment. The data collected in FAN has been used to compare and contrast changes in allosteric sites as compared to catalytic sites from multiple species to gain information about evolutionary adaptations.