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Positive association between obese postmenopausal women and breast cancer markers
Author(s) -
Alokail Majed S,
AlDaghri Nasser M,
Alkharfy Khalid M,
Draz Hossam M,
AlAttas Omar S
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.920.1
Subject(s) - breast cancer , adiponectin , medicine , obesity , endocrinology , estrogen , cancer , adipose tissue , body mass index , oncology , insulin resistance
The link between obesity and premenopausal women breast cancer development has been attributed, in part, to the fact that estrogen, a risk factor for breast cancer, is synthesized in adipose tissue. This prompted us to investigate the relationships between obesity and the presence of breast cancer markers. Hence, the purpose of this study is to pave a way for development of a blood based gene expression test for early detection of breast cancer in obese premenopausal women. We have determined the relative gene expression of adiponectin, P53, parathyroid hormone‐related peptide (PTHrP), interleukin‐6 (IL‐6), tumour growth factor‐beta (TGF‐â) in 62 samples of female subjects. The results showed Significantly increased in gene expression levels for P53, PTHrP and IL‐6, and significantly decreased levels of adiponectin were found in obese group, while the levels of TNF‐alpha and TGF‐alpha were unaltered. This data could help in explaining the mechanism behind the association between obesity and breast cancer development in premenopausal women. In conclusion, the strong positive relation of PTHrP, and P53 with Obesity in premenopausal women raises several questions for further experimentation concerning their exact role and physiological significance.