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Effect of High Fat Diet On Reproductive Cycle
Author(s) -
Ng Ka Yan,
Yong Jennifer,
Chakraborty Tandra R.
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.919.5
Subject(s) - estrous cycle , endocrinology , medicine , leptin , obesity , estrogen , hormone , infertility , biology , reproduction , physiology , pregnancy , ecology , genetics
The prevalence of obesity is on its increase largely because of the interaction between dietary intake, genes, life style and environment. The consequences of obesity include type 2 diabetes, cardiovascular disease, cancers and insulin resistance. In addition, it leads to earlier puberty, menarche in girls and infertility. There is a known effect of two hormones, estrogen and leptin on energy homeostasis and reproduction. This study is aimed to study the effect of high fat induced obesity on reproductive cycles on mice model. When mice is fed with very high fat diet (VHFD) there is an increase in the weight gain within the first week. Estrous cycle in mice goes through four stages; proestrous, estrous, metaestrous, and diestrous. Preliminary experiments on estrous cycle showed that the number of cells in the VHFD treated animals were less than the animals in normal diet indicating disruption in the reproductive cycle. Further, leptin and estrogen will be analyzed in both models to understand the interaction of hormones on VHFD treated animals.