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Metabolomic Responses of E. coli to Oxidative Stress
Author(s) -
Solimeo Renee,
Palenchar Peter
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.917.6
Subject(s) - oxidative stress , oxidizing agent , metabolite , oxidative phosphorylation , chemistry , hydrogen peroxide , biochemistry , metabolism , metabolomics , organic chemistry , chromatography
Oxidative stress can be induced by different chemicals. Hydrogen peroxide is a strong and direct oxidizer of biological molecules, copper can participate in chemicals in biological systems that can produce strong oxidizing agents, while diamide is a weak, but direct oxidizing agent that can only oxdize thiols to disulfides. Oxidative stress is known to be an important in a large number of biological processes, including metabolism, aging, and defense response, but still little is known about the metabolic responses to oxidative stress at the metabolite level. Even less is known about responses to specific oxidative affects. We will present LC‐MS data regarding levels of metabolic respones at the metabolite level of E. coli in the presence of oxidative stress inducing molecules.