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Fine structure of tubular myelin from mammalian lungs
Author(s) -
Meek Bill,
Beju Delia,
Palmer Tiffany
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.876.1
Subject(s) - lamellar granule , myelin , pulmonary surfactant , parenchyma , pathology , electron microscope , lung , extracellular , chemistry , biology , ultrastructure , biophysics , microbiology and biotechnology , central nervous system , medicine , biochemistry , neuroscience , physics , optics
Tubular myelin and intracellular surfactant images are presented from human, rabbit, rat, and dog lung. The samples represent a long‐term study of normal as well as cystic fibrosis specimens. Tubular myelin is seen in its typical lattice‐like form as it is found on the extracellular surface. Surfactant within lamellar bodies is also shown with a unique relationship to mitochondria. Images from lung parenchyma and rabbit lung washes reveal the complex architecture of tubular myelin. Specimens are fixed with glutaraldehyde and secondary fix common to electron microscopy protocols. Comparative study of cystic fibrosis samples and normal lung did not reveal any differences in tubular myelin pattern. It is hoped that an analysis of these specimens will yield further information regarding cellular surfactant production, its arrangement, and its appearance on the cell surface in both the human normal and disease condition.