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Anti‐Fertility Effects of Amlodipine in Adult Male Wistar Rats
Author(s) -
Akinlolu Adelaja Abdulazeez,
Ghazali Olaide,
Adefule Adebayo Kehinde
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.873.3
Subject(s) - amlodipine , sperm , testosterone (patch) , medicine , endocrinology , sperm motility , saline , adult male , motility , fertility , histology , andrology , biology , population , environmental health , blood pressure , genetics
Amlodipine is a long‐acting calcium channel blocker used in the treatment of hypertension and angina. In adult Man, the treatment regimen is 5 or 10mg daily. This study tested the hypothesis that prolonged oral administration of Amlodipine impairs fertility in adult male rats. Thirty‐three normotensive adult male wistar rats (140 – 250g) comprising of seven groups were employed in the study; Control Groups I and II received 4mls of Normal Saline while experimental Groups III – VII received 5, 10, 15, 20 and 40mg/kg BW of Amlodipine respectively for 56 – 65 days. Gross morphology, testicular histology, testosterone levels, sperm cells morphology, count and motility were examined in all rats. Gross morphology evaluations showed reduced bodyweight, hair loss and loss of locomotion and balance in rats treated with Amlodipine in weeks 4 – 9 in a dose‐dependent manner. No adverse effects were observed on testosterone levels in all rats. Dose ‐ dependent anomalies of sperm morphology such as sperms with no head and double tail as well as significantly reduced sperm cells' count and motility were observed in rats of the experimental group compared to rats of the control group. Histological analyses showed scanty seminiferous tubules, wider tubular lumen and reduced interstitial cells in rats of the experimental groups. This study observed impaired fertility in adult male rats treated with 5mg/kg BW or higher doses of Amlodipine. Grant Funding Source : UNIVERSITY OF ILORIN, NIGERIA