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Immunohistochemical localization of pituitary adenylate cyclase‐activating polypeptide (PACAP) and its receptor (PAC‐1) in mouse major salivary glands
Author(s) -
aka Naoko,
Nakamachi Tomoya,
Shioda Seiji,
Nakamura Masanori
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.870.1
Subject(s) - submandibular gland , endocrinology , sublingual gland , medicine , neuropeptide , myoepithelial cell , salivary gland , immunohistochemistry , pituitary adenylate cyclase activating peptide , saliva , ductal cells , biology , secretion , receptor , duct (anatomy) , chemistry , vasoactive intestinal peptide , anatomy
The control of saliva secretion is mainly under the autonomic nervous control. PACAP is now recognized as the multi‐functional neuropeptide in various organs. We compared the distribution of PACAP and PAC‐1, in major salivary glands; parotid, submandibular and sublingual glands, of young and old C57BL/6 mice. In parotid gland, PACAP was mainly detected in the cells of intercalated ducts. PAC‐1 was detected in the cells of striated duct. In submandibular gland, PACAP was distributed in the nerve fibers adjacent to acini and granular ducts and the strong immunoreaction of PAC‐1 was detected in the tall columnar epithelial cells in granular ducts and some of the cells in the striated ducts. In sublingual gland, while PACAP‐positive neural fibers surrounded the acini, PAC‐1 was expressed mainly in the epithelial cells of striated ducts. These results indicated the PACAP‐positive innervations in three major salivary glands in young and old mice and also suggested the functional differences of PACAP between three salivary glands. Supported by the Grant‐in‐Aid for Scientific Research (20592148, 21592342) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.