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Hindbrain neurovascular architecture in zebrafish and goldfish
Author(s) -
Rahmat Sulman,
Gilland Edwin
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.869.1
Subject(s) - hindbrain , anatomy , rhombomere , biology , neurovascular bundle , fourth ventricle , basilar artery , zebrafish , neuroscience , central nervous system , medicine , biochemistry , gene , hox gene , transcription factor
Vascular dye injections and confocal microscopy, combined with transgenic or retrograde neuronal labeling, were used to document the hindbrain neurovascular architecture in larval and adult cyprinid fish (zebrafish & goldfish). The data provide initial assessments of the neurovascular territories of central arterial stems and the specific blood supplies to particular hindbrain nuclei. The hindbrain central arteries arose from the basilar artery as a segmental series of 8 to 11 unpaired vessels that penetrated the pial midline of each rhombomere (r). The arteries branched into vascular trees within the hindbrain neuroepithelium near the ventricular surface, continued branching towards the pial surface and ended as small, unbranched channels that traversed nuclei and fiber tracts. These capillaries then joined to form tributary vessels of a large pial venous plexus. Notably, the neurovascular territories supplied by central arterial stems in r3 and r8 were by far the largest. The r3 stem served trigeminal motor nuclei in r2–3, as well as migrated facial motoneurons in r6–7 via long descending branches. A single large stem in r8 served most of the vagal lobe, with stems in r4–7 and caudal r8 supplying smaller zones. The data showed that hindbrain vascular and CNS elements are patterned in relation to the early rhombomeric segmental framework, with aspects of the segmental plan being maintained in adult brains. Grant Funding Source : None