Premium
AN AIRWAY ANTI‐INFLAMMATORY ROLE FOR FISH OIL SUPPLMENTATION
Author(s) -
Ade Carl J,
Rosenkranz Sara K,
Harms Craig A
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.864.5
Subject(s) - fish oil , medicine , inflammation , arachidonic acid , airway , endocrinology , chemistry , biochemistry , biology , fish <actinopterygii> , surgery , fishery , enzyme
Environmental and dietary factors cause airway immune cells to produce mediators that increase tissue inflammation and smooth muscle constriction. A high‐fat meal is one stimulus that may increase airway inflammation in healthy individuals. Supplementation with omega‐3 fatty acids can have anti‐inflammatory properties via modification of arachidonic acid metabolism. Aim To determine if omega‐3 fatty acid supplementation via fish oil will mitigate the airway inflammatory response induced by a single high‐fat meal (HFM). Methods Non‐asthmatic males (22±3 yrs) were supplemented with 3 mg×day‐1 fish oil (FO; n=5) or a placebo (CON; n=6) for 3 weeks. Exhaled nitric oxide (eNO; a marker of airway inflammation), impulse oscillometry, pulmonary function, and triglycerides were measured prior to and 2 hours following a HFM. Results Following a HFM, triglycerides increased in both FO and CON groups (79% and 118% respectively, P<0.05). The increase in eNO was higher in the CON group compared to the FO group (26.6 ± 19.6% vs. −2.6 ± 13% respectively, P<0.05). FVC was decreased in the CON group (5.32 ± 0.77 pre‐HFM vs. 5.12 ± 0.76 l post‐HFM, P<0.05) but was unchanged in FO group (4.88 ± 0.91 pre‐HFM vs. 4.88 ± 0.80 l post‐HFM, P>0.05). Conclusion A HFM increases airway inflammation and decrease pulmonary function. Omega‐3 fatty acid supplementation via fish oil protects against HFM associated changes in airway health.