Premium
Angiotensin Converting Enzyme Exerts System Control Over Fuel Handling In Skeletal Muscle
Author(s) -
Flueck Martin,
Vaughan David,
Allwood William,
Hoppeler Hans,
HuberAbel Felicitas,
Rittweger Joern,
Dunn Warwick,
O'Hagen Steven,
Goodacre Royston
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.862.5
Subject(s) - medicine , endocrinology , genotype , angiotensin converting enzyme , skeletal muscle , aerobic exercise , allele , vo2 max , biology , chemistry , biochemistry , gene , blood pressure , heart rate
Using a genetical metabolomics approach we assessed whether altered energy supply in locomoter muscle underlies the elevated aerobic performance of human genotypes containing a silencer region (I‐allele) of the major regulatory enzyme of vasoconstriction, angiotensin converting enzyme (ACE). Extensor muscle, m. vastus lateralis , of ACE‐II/ID genotypes holding the I‐allele demonstrated a trend for elevated capillarity compared to ACE‐DD counterparts lacking the I‐allele (311.0 vs. 279.7 mm‐2, n=20, p=0.10). In untrained subjects, maximal oxygen uptake during bicycle exercise was lower in ACE‐DD genotypes (44.9 vs. 47.8 ml O2/min/kg). Exhaustive aerobic exercise selectively reduced low density lipoproteins in serum of ACE‐II/ID genotypes (−14%) but was spared in ACE‐DD (+6%, p=0.25). By contrast, non‐polar metabolites in exercised muscle, comprising tentatively identified LDL‐derived glycerophosphocholine species, were depleted in ACE‐DD genotypes (q=2.8%; statistical analysis of microarrays). The interaction effect of exercise and genotype on lipidic muscle metabolites was maintained in trained subjects (p=0.03, ANOVA). The observations indicate that elevated import of serum lipids into exercised muscle underlies the enhanced aerobic exercise performance of I‐allelic genotypes for this major checkpoint of vascular perfusion.