Premium
Histological evidence for a differential regulatory role of the pituitary hormones on intestinal mucosa and its lymphoid associated cells
Author(s) -
QuintanarStephano Andrés,
CárdenasJaramillo Luz María,
JarilloLuna Rosa Adriana,
RiveraAguilar Victor,
OliverAguillón Gabriela,
CamposRodriguez Rafael,
Kovacs Kalman,
Berczi Istvan
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.852.1
Pituitary hormones regulate body growth, cell differentiation and function, including the immune system. PRL, GH and vasopressin (AVP) modulates/stimulates whereas the HPA axis modulate/suppress the immune responses. However, the role of pituitary hormones on the gut‐associated lymphoid tissue (GALT) is not well known. Here, histological evidence for a differential role of the pituitary hormones on the mucosa and GALT is reported. Young male Wistar rats were sham operated (SHAM), hypophysectomized (HYPOX), and anterior (AL) or neurointermediate pituitary lobectomized (NIL). Three weeks after surgeries, ileum histological slides were stained with PAS and immunostained for CD4+ and CD8+ lymphocytes ( Ly ). Size of intestinal villi and goblet cell number per villi were assessed and lamina propria and intraepithelial Ly counted per area unit. As compared with the SHAM, the size of villi decreased significantly in AL, NIL and HYPOX groups (25%, 22% and 34%), whereas the goblet cells decreased significantly in both AL (38%) and HYPOX (27%) animals. The numbers of lamina propria CD4+ Ly were significantly decreased in NIL and HYPOX groups, whereas CD8+ Ly decreased significantly only in the HYPOX group. Intraepithelial Ly were significantly decreased only in NIL animals. It seems that intestinal villi and goblet cells are more dependants on GH, whereas GALT is more dependant on AVP and oxytocin. Supported by UAA and CONACYT. México.