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Intracardiac Angiotensin II Is Not Modified By A Cholesterol Enriched Diet
Author(s) -
Minas Jacqueline Norma,
Rodriguez Ruben,
Aguil Jennifer,
Nakano Daisuke,
Nishiyama Akira,
Ortiz Rudy M.
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.848.10
Subject(s) - olmesartan , medicine , endocrinology , cholesterol , angiotensin ii , blockade , metabolic syndrome , diabetes mellitus , blood pressure , receptor
Blockade of the renin‐angiotensin system has shown to alleviate cardiovascular abnormalities in diabetic models. Furthermore, an increase in cholesterol intake can lead to CVD. However, the effects of angiotensin receptor blockade (ARB) on heart Ang II content in a model of metabolic syndrome on a high cholesterol diet are unknown. Using a rat model of metabolic syndrome (OLETF) and lean controls (LETO), we supplemented these rats with high cholesterol diet (2%) (HCD) and/or treated with an ARB (10 mg olmesartan/kg/d) for 16 wk. We used an additional group of OLETF in which ARB was removed 5 wk before the end of the study. SBP of all LETO groups remained lower than all OLETF groups. HCD had no effect on SBP in either LETO or OLETF groups, but ARB was effective in all cases of normalizing SBP. Removal of ARB for 5 wk caused SBP to return to elevated levels (similar to OLETF & OLETF + HCD). HCD had no effect on heart Ang II levels in either LETO or OLETF rats; however, in all cases ARB was effective in reducing heart Ang II 20–30%. Removing ARB increased heart Ang II 32% compared to OLETF HCD/ARB suggesting that sequestration of Ang II in the heart is AT1‐mediated in a metabolic syndrome model. The data would suggest that CV complications associated with HCD are not associated with inappropriately elevated cardiac Ang II levels; however, treatment with an ARB is important under these conditions to normalize SBP. Funded by NIH NCMHD 9T37MD001480.