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LONG TERM FEEDING OF FRUCTOSE IS ASSOCIATED WITH VASCULAR RENAL FUNCTION
Author(s) -
Yokota Rodrigo,
Farah Vera,
Fiorino Patricia,
Leite Ana Paula,
Fonteles Manassés C.,
Casarini Dulce Elena
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.839.14
The purpose of this study was to evaluate the renal function by an extracorporeal renal perfusion method as well as the contribution of rennin angiotensin system (RAS) in blood pressure (BP) in rats subjected to a fructose overload. Male Wistar rats (n=5/group) were divided in Control group (CG) and Fructose group (FG)(10%, drinking water, 8 weeks). The renal function was evaluated in isolated perfusion rat kidney with Krebs‐Henseleit solution, containing 6g of previously dialyzed bovine serum albumine. BP were measured by tail method on the animals through the use of sphygmomanometer at the 8th weeks. BP in FG was higher than CG. Perfusion pressure (PP) and renal vascular resistance (RVR) were higher at 90min than at 30min (internal control), however, urinary flow (UF) was unchanged in FG. CG had no significant effect for any of renal parameters evaluated. In conclusion these preliminary observations demonstrate that the association of risk cardiovascular factors determined alterations in renal function that could be due at least in part to the activation of the renin angiotensin system in this ex‐vivo model. Financial Support: PIBIC Mackenzie/MackPesquisa, FAPESP Process nº 52556‐7/2009, and CAPES