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Salt sensitivity of blood pressure in a rat model of polycystic ovary syndrome
Author(s) -
Moulana Mohadetheh,
Lima Roberta,
Reckelhoff Jane F.
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.837.1
Polycystic ovary syndrome (PCOS) is the most common hormonal disorder among women of reproductive age. Enlarged ovaries containing numerous small cysts, elevated androgen level, and insulin resistance are among the main symptoms of PCOS. We have characterized a rat model of PCOS, the hyperandrogenemic rat (HAF), that exhibits characteristics of PCOS in women. The aim of this study was to investigate whether the hypertension in HAF rats, is salt sensitive. Dihydrotestosterone (DHT) (7.5 mg/90 days or placebo)pellets were implanted subcutaneously in female SD rats (n = 5/group) at 4weeks of age and compared to placebo. After 4 weeks of DHT treatment, radiotelemetry probes were implanted to measure mean arterial pressure (MAP). HAF rats (10 wk old, 6 wk DHT or placebo) were placed on 0.5% NaCl drinking water and 0.1% NaCl food, 1% NaCl or 1.5% NaCl in drinking water with 1% NaCl food, each for 7 days. Urinary sodium excretion was measured on days 6, 13, and 20. Pressure‐natriuresis curves were drawn using MAP's on days 5, 12, and 19. As shown in the figure, HAF rats have a rightward parallel shift of the pressure‐natriuresis relationship compared to placebo. These data show that the hypertension in HAF rats is not salt‐sensitive, and suggest that women with PCOS may not be salt sensitive. This Study was supported by NIH HL69194, HL66072, and POL HL51971.