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High‐salt intake during pregnancy is associated with cardiac concentric hypertrophy in male offspring in response to a high salt diet during adulthood
Author(s) -
Rodrigues Edson Nogueira Alves,
Katayama Isis Akemi,
Oliveira Ivone Braga,
Furukawa Luzia Naoko Shinohara,
Rosa Kaleizu Teodoro,
Veras Mariana M,
Heimann Joel Claudio
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.836.12
Objective to evaluate the effects of low or high salt intake during pregnancy on cardiac structure of male offspring at birth and adulthood. Methods Low (LS, 0.15%), normal (NS, 1.3%) or high‐salt (HS, 8% NaCl) diet was given to Wistar rats during pregnancy. During lactation all dams received NS as well as the offspring after weaning. To evaluate cardiac response to salt overload, 50% of each group was fed a HS (hs, 4% NaCl) diet from the 21 st to the 36 th week of age (LShs, NShs, HShs). The other 50% was maintained on a NS (LSns, NSns and HSns). Heart to body weight ratio (H/B‐g/kg) was measured at birth. Echocardiography was done at 30 weeks of age. Cardiomyocyte cross‐sectional area (CSA‐μm 2 ) and mean arterial blood pressure (MBP‐mmHg) were measured at 36 weeks of age. Results (mean ± SEM, p<0.05, n=5–8): H/B was higher in HS (6.41±0.19) compared to NS (5.69±0.12) and LS (5.88±0.19). In adulthood, relative wall thickness and CSA was higher (p=0.06 and p<0.05) in HShs (0.45±0.02 and 251±19) compared to NShs (0.39±0.02 and 193±9) and LShs (0.39±0.01 and 202±7) respectively, suggesting concentric hypertrophy. MBP was lower in LShs (109±5) compared to NShs (121±3) and HShs (126±2). Conclusions HS intake during adulthood reveals the cardiac consequences of a HS diet during pregnancy. This effect is not related to the blood pressure response to a HS intake.