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Elevated plasma levels of soluble TNF‐alpha Receptor 1 (sTNFR1) in preeclampsia associated with fetal growth restriction
Author(s) -
ferreri nicholas r,
Hao Shoujin,
Fava Cristiano,
Amen Gabriella,
Meneguzzi Alessandra,
Pedraza Paulina,
Zanconato Giovanni,
Minuz Pietro
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.836.10
A cross‐sectional study comparing women with preeclampsia (PRE, n=19), normotensive pregnant women (N, n=32) pair matched for gestational age (24–40 wks, median 34 and 37, respectively), and non‐pregnant women (C, n=19) matched for age and BMI (below 27 Kg/m2) was performed to evaluate the role of sTNFR in PRE. Creatinine clearance was reduced in PRE (median 105 mL/min; range: 68–117) compared with N (114; 97–232, P<0.0001), while serum uric acid was higher. C‐reactive protein was elevated in pregnancy (PRE: 2.5 mg/L, 0.4–19.6; N: 2.5, 0.2–10.3) compared with C (0.6, 0.15–3.0, P<0.01). Plasma sTNFR1 levels were higher in PRE (1450 pg/mL, 508–4005) and N (950, 139‐2192) compared with C (432, 44‐1480, P<0.001) with the highest values observed in PRE with IUGR (2529 pg/mL, 992‐4005, n= 6, P<0.05 vs N, P<0.001 vs C). sTNFR2 was higher in both groups of pregnant women (PRE: 1667 pg/mL, 852‐4008; N:1755, 319‐3416) compared with C (1081, 411‐1943, P<0.01). Plasma sTNFR1 correlates with systolic blood pressure (r = 0.40, P<0.001, n=70), body weight of the newborn (r= −0.43, P<0.01, n=51), and placental weight (r= −0.37, P<0.05). TNFR1 and R2 mRNA accumulation was elevated in placenta but not peripheral blood leukocytes from PRE. These data suggest that increased levels of sTNFR1 in plasma reflect activation of the TNF pathway and are related to reduced feto‐placental development in preeclampsia.