Polymorphism of Adiponectin Receptor Gene Type 1 (ADIPOR1) in Diabetic Patients Presenting with Coronary Artery Disease

The aim of the study is to investigate the associations of the genetic marker (SNP) of AdipoR1 locus; rs10920531 and rs7539542 with coronary artery diseases [CAD] in patients with and without type2 diabetes in Arab populations. Previous studies demonstrated polymorphisms of adiponectin receptor type1 [AdipoR1] as strong determinant of CAD susceptibility in type 2 diabetes. Methods blood was drawn from 189 patients and genotyping of extracted DNA was carried out by the 5′ nuclease assay using TaqMan MGB probe by means of an ABI 7900. Results both groups of CAD with and without DM had insignificant difference of the followings parameters; age, BMI, glucose, lipid profile, cardiac enzyme markers, insulin and adiponectin. The frequency distribution of the genotype (rs1092531, A>C) revealed that (35.1%), [35.8%], had AA and (41.5%), [41.1%] had AC, and (23.4.0%), [23.1%] had CC among control and cardiac patients with and without DM, respectively with P value=0.94. The Odds ratio was 1.02 and 95% CI was (0.85–1.43). The frequency distribution of the genotype (rs7539542, C>G) revealed that (34.0%), [41.1%], had CC and (47.9%), [34.7%] had CG, and (18.1.0%), [24.2%] had GG among control and cardiac patients with and without DM, respectively with P value=0.37. The Odds ratio was 0.98 and 95% CI was (0.65–1.47). Using logistic regression analysis, low density lipoprotein [LDL‐C] was significantly associated with both rs1092531, A>C and rs7539542, C>G in CAD patients. Hypertension was significantly associated with rs7539542. Conclusion No significant association was found between AdipoR1 locus; (rs1092531, A>C and rs7539542, C>G) and the CAD. Of all CAD risks, Only LDL‐C correlated significantly with (rs1092531, A>C and rs7539542, C>G). Hypertension was significantly associated with rs7539542. The study was supported by a grant# UREP: 06 ‐ 076 ‐ 3 – 018 by Qatar National Research Fund.