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Endothelial function in obesity and metabolic syndrome: role of ROS
Author(s) -
Harrell John William,
Limberg Jacqueline K,
Linstroth Lee A,
Eldridge Marlowe W,
Proctor Lester T,
Sebranek Joshua J,
Schrage William G
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.821.9
Poor endothelial function (EDD) has been demonstrated in older obese adults (45–70 yr), due in part to excess reactive oxygen species (ROS). We hypothesized that acute scavenging of ROS would increase EDD in younger obese and metabolic syndrome (MetS) adults. Eight Lean (26±3 yr, BMI 22±1 kg.m −2 ), 11 Obese (35±4 yr, BMI 37±2 kg.m −2 ), and 12 MetS (35±3 yr, BMI 39±2 kg.m −2 ) subjects were instrumented with a brachial artery catheter (BP and drug infusion). Forearm blood flow (FBF) was measured using Doppler ultrasound. EDD (acetylcholine, ACH) and vascular smooth muscle function (sodium nitroprusside, SNP) were tested before and after infusion of Vitamin C (VitC). FBF was normalized for blood pressure and forearm volume. MetS response to ACH was higher than lean (p<0.01). There was no difference in SNP response between groups. VitC increased obese ACH response 72% (p=0.03). VitC increased SNP response in lean 114% (p=0.05) and obese 44% (p=0.03). ACH and SNP responses were unchanged with infusion of VitC in MetS. VitC increased plasma total antioxidant capacity in all groups (p=0.02). In contrast to older obese adults, young obese and MetS adults demonstrate preserved EDD. ROS scavenging can increase EDD in obese adults, in part by increasing vascular smooth muscle responsiveness, but had no effects in MetS. Support: NIH HL091397 (WGS).