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Noninvasive regional oximetry correlates with direct laser doppler measurement of intestinal perfusion
Author(s) -
Cizenski Jeffrey David,
Robinson Kortney,
Hojnowski Kristen,
Roy Shreyas,
Sadowitz Benjamin,
Snyder Kathleen,
Gatto Louis,
Nieman Gary
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.814.21
Subject(s) - laser doppler velocimetry , perfusion , medicine , cardiology , blood flow
Regional oximetry has recently been established as a reliable, noninvasive method of monitoring cerebral perfusion in stroke patients. This novel technology uses near‐infrared spectroscopy (NIRS) to measure regional oxygen saturation (rSO2) and has enabled early identification of compromised cerebral perfusion induced by stroke, thus improving ischemic intervention response time. The objective of this study was to test the hypothesis that rSO2 would correlate with definitive measures of intestinal perfusion. Acute mesenteric ischemia is notoriously difficult to diagnose without invasive arteriography and the resultant delay in treatment contributes to its high 50% mortality. Our specific aim was to determine if rSO2 could serve as a noninvasive indicator of gut perfusion. METHODS Pigs (n=2) were anesthetized and instrumented for monitoring. Through a laparotomy, a laser doppler flowprobe (Transonic® Inc) was sutured to the serosa of the ileum for measurement of perfusion. A rSO2 probe (Nonin Inc. Equanox Regional Oximeter™) was placed on the abdominal wall directly over the Doppler probes. Gut perfusion was altered by graded clamping of the superior mesenteric artery. RESULTS See figure, R 2 = .94. CONCLUSIONS Regional oximetry can identify a reduction in gut perfusion, which may improve diagnosis of acute mesenteric ischemia. The source of funding is: NIH grant 1R33HL089076‐01A1