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Anti‐inflammatory and antioxidant effect of atranorin extracted from Cladina kalbii AHTI
Author(s) -
Quintans Jullyana Siqueira,
Siqueira Rosana Souza,
Araujo Bruno Eduardo Silva,
Guimarães Adriana Gibara,
Bonjardim Leonardo Rigoldi,
Araújo Adriano,
Gelain Daniel,
DeSantana Josimari,
QuintansJunior Lucindo
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.807.4
Aim of this study was to investigate the anti‐inflammatory and antioxidant effects of atranorin (AT). Leukocyte migration to the peritoneal cavity: thirty male swiss mice received AT (100–400 mg/kg, i.p.), vehicle (saline + 0.2% Tween 80) or dexamethasone (DEXA, 2 mg/kg, s.c.), 0.5 h before carrageenan injection (500 μg/cavity, 500 μl) in the peritoneal cavity. The total cells were counted in Neubauer chamber. Carrageenan and Arachidonic acid‐induced hind paw edema: thirty male wistar rats received AT, vehicle or DEXA as previous test, 0.5 h before inflammatory agents injection into the subplantar of right hind paw. The paw volume was measured at 0 (just before) ‐ 4 h after the inflammatory agents injection. Total radical‐trapping antioxidant parameter and total antioxidant reactivity: the capacity of AT to trap a flow of water‐soluble peroxyl radical produced was evaluated through thermal decomposition of AAPH. AT exhibited significant anti‐inflammatory activity in acute tests. Also, AT exhibited in vitro antioxidant activity. Our results suggest that AT might represent important tool for treatment of inflammatory disorders. Financial support: FAPITEC/SE/Brazil; CNPQ/Brazil.