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Effect of Gmelina arborea extract in STZ induced type I diabetic rats
Author(s) -
Kulkarni Yogesh Anant,
Veeranjaneyulu Addepalli
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.805.9
Subject(s) - gmelina , streptozotocin , traditional medicine , medicine , chemistry , endocrinology , diabetes mellitus , biology , botany
Diabetes mellitus, a global public health problem, is now emerging as an epidemic world over. The total number of people with diabetes is projected to rise from 171 million in 2000 to 366 million in 2030. Gmelina arborea is an important phytomedicine used in traditional system for treatment of diabetes. The objective of the present study was to investigate the effects of methanol extract of Gmelina arborea bark (ME) in streptozotocin (STZ) induced type I diabetes in rats. Diabetes was induced in rats by the intraperitoneal injection of STZ at a dose of 55 mg/kg. The diabetic animals (plasma glucose >250 mg/dl) were divided into four groups‐ Group I diabetic control, Group II and III, ME treated (250 and 500 mg/kg/day) and Group IV glibenclamide (0.6 mg/kg), along with these groups there was one age matched control group also. The ME and glibenclamide were administered 28 days consecutively. Plasma glucose levels, body weight, food and water intake were determined up to 4 weeks. Different biochemical parameters like cholesterol, HDL, triglycerides, AST, ALT, ALP, total proteins, albumin, creatinine and BUN were determined on day 28. Oral administration of ME for 28 days resulted in significant reduction (p<0.001) in plasma glucose levels. ME also showed inhibition of reduction in body weight and significant decrease in food and water intake in diabetic animals. ME at selected doses showed significant reduction the creatinine level (p<0.05) and BUN level (p<0.01) significantly. The findings suggest significant activity of the medicinal plant in experimentally induced diabetes.