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Adaptive growth features of rat cholestatic liver
Author(s) -
Modebadze Irina,
Bakuradze Ekaterine,
Ninua Levan,
Dekanoidze Davit,
Dzidziguri Diana
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.794.3
It is known that along with proliferation a high profile is given to a cell hypertrophy and polyploidy in restoration of structure and function of various organs. It is established that the age, metabolism, intensity of blood circulation in damaged tissue, concomitant diseases can reduce, enhance or qualitatively change regenerative processes. Regenerative ability of each organ gets the form providing the most effective ways of functions restoration. For example, enhancement of hepatocyte hypertrophy and polyploidy is observed at a certain stage of regenerative process in liver with chronic hepatitis. The aim of the present work was to study the adaptive growth features of rat cholestatic liver. The investigations were carried out on 50 adult (150–180 g) rats. For the modelling of cholestatic liver common bile duct ligation was performed. Preservation of liver functional abilities in cholestatic liver is carried out by increasing of hepatocite ploydy (4c, 4cx2, 8c) in the first 96 hours. It is essential that at the same time the hepatocyte mitotic index reaches its maximal value. We have established that high mitotic activity provides both processes proliferation and polyploidy. In particular the quantity of diploid and binuclear (2cx2) cells is increased but polyploid cells (4c, 8c) remain the same on the 5 th day after common bile duct ligation. According to our results, we can conclude that the priority is given to different ways of regeneration depending on duration of cholestasis and liver damage rates.