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Serum immunoglobulin E levels and dietary intake of Korean infants and young children with atopic dermatitis
Author(s) -
LEE SANGEUN,
Jo Sunmi,
Chung SangJin,
Ahn Kang Mo,
Lee Sang Il
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.784.14
Subject(s) - atopic dermatitis , medicine , immunoglobulin e , immunology , antibody
Atopic dermatitis (AD) has become a serious epidemic in Korean children. We aimed to identify dietary factors associated w/serum total and food allergen‐specific IgEs. A total of 119 children (0–24 mo) diagnosed w/AD were recruited from a medical center, Seoul. For dietary data collection of children and mothers who breastfed for more than one mo after diagnosis of AD, a 24h recall and a semiquantative FFQ were used. Serum total and six allergen‐specific IgEs (spe‐IgE) measured by CAP‐FEIA. Multiple linear regression was performed to estimate the coefficients b/w IgEs and dietary intake. Total IgEs were associated positively w/CHO and ω‐6/ω‐3 ratio; inversely with energy intake (p<0.05). Positive associations were found b/w CHO intake and specific IgEs to egg white, milk and soy (p<0.05); vit E and spe‐IgE to milk and wheat; ω‐6/ω‐3 ratio and spe‐IgEs to milk, wheat, buck wheat and soy (p<0.05). Fat intake was inversely related w/spe‐IgEs to egg white and milk (p<0.01). Inversely associated w/maternal dietary intake during lactation was fat w/all spe‐IgEs (p<0.05); vit E w/spe‐IgEs to milk, wheat, soy and peanut; ω‐6 fatty acid w/spe‐IgE to milk (p<0.05). Evidences from our study seem to suggest that ω‐3 intake, not vit E, may possibly lower total and spe‐IgEs in infants and children w/AD. This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (KRF‐2007‐331‐C00281).