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Dietary total antioxidant capacity is inversely associated with cardiovascular disease risks in overweight postmenopausal women
Author(s) -
Yang Meng,
Wang Ying,
Davis Catherine G.,
Lee SangGil,
Kenny Anne,
Chun Ock K.
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.783.9
Despite emerging interest in dietary total antioxidant capacity (TAC), the application of dietary TAC in predicting CVD risks has not been well documented in high‐risk population. This study aimed to investigate the association between dietary TAC and biomarkers of CVD risks in overweight postmenopausal women. Seven‐day diet recalls, health parameters and 12h fasting blood samples were collected in 40 overweight healthy postmenopausal women. The average of dietary TAC and TAC from diet and supplements were 686.6 and 832.5 vitamin C equivalent per day, respectively. Energy adjusted dietary TAC was inversely related with LDL level (P < 0.05), marginally with total cholesterol (P < 0.1), and negatively associated with odds ratio of CRP > 3 mg/L (P < 0.05). Dietary TAC was positively associated with catalase level (P < 0.05), while marginally negatively associated with superoxide dismutase activity (P < 0.1) after adjusted for relevant covariates. TAC from diet and supplements present similar trends as dietary TAC but these correlations were attenuated. The findings indicated that dietary TAC is inversely associated with CVD risks possibly through ameliorating CVD risks and improving endogenous antioxidant defense. The implicated application of dietary TAC for predicting CVD risks warrants to be validated in other specific populations. Grant Funding Source : Donaghue Nutrition Research Program