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Association between glutathione S‐transferase (GST) M1 and T1 Polymorphisms and subclinical hypertension in Korean population
Author(s) -
Han Jeong Hwa,
Lee Hye Jin,
Cho Mi Ran,
Yun Kyung Eun,
Choi Hee Jeong,
Kang MyungHee
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.782.8
Human hypertension is a major health problem worldwide, and is classified as a complex, multifactorial, polygenic disease despite its genetic components remains unknown. The importance of oxidative stress in hypertension has recently been paid more attention. Glutathione S‐transferase (GST) forms a multigene family of phase II detoxification enzymes which is involved in detoxification of reactive oxygen species. In this study, the association between the incidence of hypertension and a family of antioxidant enzymes, GSTM1 and GSTT1, polymorphisms was investigated in 227 newly‐diagnosed, untreated, subclinical hypertensive patients (systolic blood pressure (BP) ≥ 130 mmHg and diastolic BP ≥ 85 mmHg) and 130 normotensive subjects (systolic BP < 120 mmHg and diastolic BP < 80 mmHg) in a health screening program. The frequency of the GSTM1‐null genotype in hypertensive patients (68.3%) was significantly higher than in normotensives (50.0%, p<0.01). However, there was no difference between the frequency of the GSTT1‐null genotypes in hypertensives (66.5%) and in normotensives (66.9%). The frequency of the subjects having both the GSTM1 and GSTT1 null genotypes (48.5%) was significantly higher than those in normotensives (36.2%, p<0.01). Compared to both the GSTM1 and GSTT1 wild genotypes in hypertensives (13.7%) and in normotensives (19.2%) respectively, the frequency of both the GSTM1 and GSTT1 null genotypes in hypertensives (48.5%) and in normotensives (36.2%) were significantly high (p<0.01). Our study confirmed that GSTM1‐null genotype is a potential genetic factor to predict development of subclinical hypertension in Korea. (This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2010‐0012031)).