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The PPARγ Pro12Ala Polymorphism and Dietary Polyunsaturated Fatty acids in Relation to Inflammation
Author(s) -
Wang Huifen,
Steffen Lyn M,
Mashek Douglas,
Gross Myron
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.782.3
Polyunsaturated fatty acid (PUFA) intake is related to inflammation. This relationship may be modified by genetic variation in a major regulator of lipid metabolism, the peroxisome proliferator‐activated receptor γ (PPARγ). The Pro12Ala polymorphism may modify the relation between dietary PUFA intake and markers of inflammation (IL‐6, CRP, fibrinogen). Gender‐specific cross‐sectional analysis was conducted among blacks and whites (n=2690) completing the year‐20 CARDIA Study exam. In both genders, a significant modification effect of Pro12Ala was found for the relations of IL‐6 (but not CRP or fibrinogen) with arachidonic acid (AA) and ω3 FA (Table). The relations of IL‐6 with AA and ω3 FA were positive in male Ala allele carriers, inverse in female Ala carriers, and no relation in Pro homozygotes. The findings suggest that greater PUFA intake may be more beneficial for female Ala carriers than non‐carriers. Longitudinal studies are needed to examine PPARγ Ala12Pro genotype/PUFA relations on inflammation. Grant Funding Source : NIH/NHLBI N01‐HC‐48048