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Treatment with High Saturated Fat Diet, compared with Standard Diet and High n‐3/n‐6 Polyunsaturated Fat Diet, Decreases Mortality in Cardiomiopathic Hamsters
Author(s) -
Fatima Goncalves Galvao Tatiana,
Brown Bethany,
O'Connel Kelly,
Hecker Peter,
Stanley Willian C
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.777.2
Background The optimal fat intake for heart failure (HF) patients is not known. We compared high fat diets rich in polyunsaturated (PUFA) or in saturated fat (SF) to a standard low fat diet (SD) in a HF model. Methods Male cardiomyopathic (CMH) Syrian hamsters (Bio TO‐2 strain), 6 weeks of age, were assigned to 3 diets: SD (15% energy as fat); high PUFA (45% fat); High SF. Mortality was assessed (n=30/group), and subgroups were studied after 24 weeks of treatment. CMH develop severe mitochondrial dysfunction, therefore we isolated mitochondria to assess respiration and Ca2+‐induce permeability transition pore (MPTP) opening. Results Among CMH there was no difference in body mass or left ventricular ejection fraction. Mitochondrial yield and respiratory function were impaired in CMH vs. healthy control hamsters. Mitochondrial respiration, coupling and Ca 2+ ‐induced MPTP opening were not different among CMH groups. On the other hand, PUFA diet increased fat pad mass by 30% (P<0.05) compared with the SD or SF diets. Plasma free fatty acids levels were elevated in the PUFA diet compared to SD (p<0.05). Importantly, survival was prolonged in CMH fed the SF diet compared to either SD or PUFA diets (p<0.01) Conclusion Treatment with a high SF diet decreased mortality compared to SD or to PUFA diet in CMH, but this effect was not due to improvement in mitochondrial function, suggesting novel unidentified mechanisms are involved.